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Characterizing and deciphering the interaction of human platelets and platelet-derived proteins with Streptococcus pneumoniae and Staphylococcus aureus / vorgelegt von Ulrike Binsker

Staphylococcus aureus, Streptococcus pneumoniae, Thrombospondin, platelets

PPN (Catalogue-ID): 1016286023
Personen: Binsker, Ulrike [VerfasserIn]
Hammerschmidt, Sven [GutachterIn]
Preissner, Klaus T. [GutachterIn]
Cooperations/Conferences: Ernst-Moritz-Arndt-Universität Greifswald [Grad-verleihende Institution]
Format: eBook eBook
Language: English
Published: Greifswald, 22. September 2017
Hochschule: Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Ernst-Moritz-Arndt-Universität Greifswald, 2018
Basisklassifikation: 44.75
35.76
44.43
Subjects:

Staphylococcus aureus / Streptococcus pneumoniae / Thrombospondin / Thrombozyt

Formangabe: Hochschulschrift
Notes: Literaturverzeichnis: Seite 40-59.
Physical Description: 1 Online-Ressource (PDF-Datei: 181 Seiten, 40121 Kilobyte), Illustrationen (teilweise farbig), Diagramme (teilweise farbig).

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520 |a Staphylococcus aureus, Streptococcus pneumoniae, Thrombospondin, platelets 
520 |a Streptococcus pneumoniae (pneumococci) and Staphylococcus aureus (S. aureus) are human-specific commensals of the upper respiratory tract. Every individual is asymptomatically colonized with both bacteria at least once in their life-time. The opportunistic pathogens can affect further organs and invade into deeper tissue. The occupation of normally sterile niches of the human body with the bacteria can lead to local infections such as sinusitis, otitis media and abscesses, or to life-threatening diseases like pneumonia, meningitis or sepsis. A strong interaction between the bacterium and the respiratory epithelial cells is a prerequisite for a successful colonization. This interaction is ensured by bacterial surface proteins, so called adhesins. The binding of the adhesins to the epithelial lineage occurs predominantly indirectly via components of the extracellular matrix (ECM), but also directly to cellular receptors. Pneumococci and S. aureus bind to various ECM glycoproteins, amongst others: fibronectin, fibrinogen, vitronectin, and collagen. Also binding of both pathogens to human thrombospondin-1 has been described. Thrombospondin-1 is mainly stored in the α-granula of thrombocytes (platelets) and released into the circulation upon activation. However, thrombospondin-1 is also produced and secreted by other cell types like endothelial cells, macrophages, and fibroblasts, which gets subsequently incorporated as component into the ECM. So far, no thrombosponin-1-binding ... 
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