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Orphan G Protein-Coupled Receptors and Novel Neuropeptides / edited by Olivier Civelli, Qun-Yong Zhou

Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physi... Full description

PPN (Catalogue-ID): 571014275
Personen: Civelli, Olivier
Zhou, Qun-Yong
Format: eBook eBook
Enthält: CONTENTS; The Orphanin FQ/Nociceptin (OQ/N) System; 1 Discovery of OFQ/N; 2 Pharmacology and Cellular Responses Induced by OFQ/N; 3 Synthesis and Inactivation of OFQ/N; 4 The OFQ/N and Opioid Systems; 5 Tissue Distribution of the OFQ/N System; 6 The Functional Implications of the OFQ/N System; 6.1 Locomotion; 6.2 Pain; 6.3 Drug Dependence; 6.4 Anxiety and Stress; 6.5 Learning and Memory; 6.6 Depression; 6.7 Seizures; 6.8 Food Intake; 6.9 Cardiovascular and Renal Systems; 6.10 Cough and Bronchial Constriction; 6.11 Immune System; 7 Conclusions; References
Language: English
Published: Berlin, Springer, 2008
Series: Results and Problems in Cell Differentiation (46)
Subject Area (NLM): QU 55.7
Basisklassifikation: 42.15
44.90
RVK:

WW 2200: Biologie -- Anatomie und Physiologie von Mensch und Tier, Vorklinische Medizin -- Morphologie, Anatomie und Physiologie allgemein; Anatomie, Physiologie und Biochemie einzelner Organe und Organsysteme von Mensch und Tier -- Anatomie, Physiologie und Biochemie einzelner Organe und Organsysteme von Mensch und Tier -- Reiz- und Sinnesphysiologie allgemein, sensorische Rezeptoren -- Nervensystem insgesamt, Neurochemie, Neurophysiologie, Neuroanatomie -- Allgemeines -- Allgemeines

Subjects:

Receptors, Neuropeptide

Receptors, G-Protein-Coupled

Neuropeptides

Neuropeptide

ECHO-Viren / GTP-bindende Proteine / Rezeptor

Notes: Description based upon print version of record
Physical Description: Online-Ressource, v.: digital.
ISBN: 978-3-540-78351-0
Sekundärausgabe Online-Ausg., 2008, Springer eBook Collection. Biomedical and Life Sciences

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501 |a CONTENTS; The Orphanin FQ/Nociceptin (OQ/N) System; 1 Discovery of OFQ/N; 2 Pharmacology and Cellular Responses Induced by OFQ/N; 3 Synthesis and Inactivation of OFQ/N; 4 The OFQ/N and Opioid Systems; 5 Tissue Distribution of the OFQ/N System; 6 The Functional Implications of the OFQ/N System; 6.1 Locomotion; 6.2 Pain; 6.3 Drug Dependence; 6.4 Anxiety and Stress; 6.5 Learning and Memory; 6.6 Depression; 6.7 Seizures; 6.8 Food Intake; 6.9 Cardiovascular and Renal Systems; 6.10 Cough and Bronchial Constriction; 6.11 Immune System; 7 Conclusions; References 
501 |a Orexins and Orexin Receptors: From Molecules to Integrative Physiology1 Introduction; 2 Orexin and Orexin Receptors; 2.1 Identification of Orexin (Hypocretin) by Deorphaning of Two GPCRs; 2.2 Orexin Receptors; 2.3 Distribution of Orexin Neurons; 2.4 Distributions of Orexin Receptors; 3 Neural Circuits of Orexin Neurons; 3.1 Neuronal Afferents; 3.2 Local Interneurons; 3.3 Efferents of Orexin Neurons; 4 Roles of Orexins in Regulation of Sleep/Wake States; 4.1 Interaction with Sleep and Arousal Centers; 4.2 Interaction with Waking Centers; 5 Roles of Orexins in Feeding Behavior 
501 |a 5.1 Interaction with Hypothalamic Neurons5.2 Regulation of Orexin Neurons by Humoral Factors; 5.3 Mechanism of Orexin-mediated Feeding; 5.4 Orexin as Effect or of Food Entrainable Oscillator (FEO); 6 Roles of Orexins in Reward Systems; 6.1 Input from Reward Systems; 6.2 Output to Reward Systems; 7 Orexins in Emotion,Stress Responses and Autonomic Nervous System; 7.1 Input from Mesolimbic System; 7.2 Stress Response; 7.3 Orexin in Autonomic Nervous System; 8 Clinical Implications; 8.1 Orexin Deficiency and Narcolepsy-Cataplexy; 8.2 Orexin Agonists; 8.3 Orexin Antagonists; 9 Conclusion 
501 |a ReferencesProlactin-Releasing Peptide; 1 Molecular Pharmacology; 1.1 PrRP; 1.2 PrRP Receptor; 2 Anatomical Distribution; 2.1 PrRP; 2.2 PrRP Receptor; 2.3 Comparison Between PrRP and PrRP Receptor Expression; 3 Functional Implications; 3.1 Prolactin Release; 3.2 Stress and Anxiety Response; 3.3 Food Intake and Energy Homeostasis; 3.4 Pain Processing; 3.5 Sexual and Reproductive Functions; 3.6 Sleep and Arousal; 3.7 Press or Effects; 3.8 Other Actions; 4 Conclusion; References; Structure and Function of Ghrelin; 1 Introduction; 2 Discovery and Structure Determination of Ghrelin 
501 |a 3 Des-AcylGhrelin4 Ghrelin Gene and the Structure of the Ghrelin Precursor; 5 Enzyme for Acyl-Modification of Ghrelin; 6 Ghrelin Receptor Family; 7 Ghrelin and Motilin; 8 Distribution of Ghrelin; 8.1 Plasma Ghrelin; 8.2 Gastric and Intestinal Ghrelin; 8.3 Pancreatic Ghrelin; 8.4 Pituitary Ghrelin; 8.5 Ghrelin in the Brain; 9 Physiological Functions of Ghrelin; 9.1 Growth Hormone Releasing Activity of Ghrelin; 9.2 Appetite Stimulating Activity of Ghrelin; 9.3 Pathway of the Ghrelin Signal; from Peripheral Tissues to the Central Nervous System; 9.4 Ghrelin and Eating Disorders 
501 |a 9.5 Cardiovascular Function of Ghrelin 
520 |a Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms. The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research. 
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