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Reproductive and developmental toxicology / ed. by Ramesh C. Gupta

Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant referen... Full description

PPN (Catalogue-ID): 663129826
Personen: Gupta, Ramesh C.
Format: eBook eBook
Enthält: Front Cover; Dedication; Reproductive And Developmental Toxicology; Copyright; Contents; Foreword; List of Contributors; Section 1 - General; Chapter 1 - Introduction; Introduction; Chapter 2 - Reproductive anatomy and physiology; Introduction; Important definitions and concepts; Review of normal human reproduction; Concluding remarks and future directions; References; Chapter 3 - Bio-communication between mother and offspring; Introduction; Maternal influences on the development of the offspring; Transportation of bioactive substances between mother and offspring
Language: English
Published: Amsterdam, Elsevier, Acad. Press, 2011
Edition: 1. ed.
Subject Area (NLM): WQ 205 R4228 2011
RVK:

XI 2150: Medizin -- Pharmakologie und Toxikologie -- Allgemeine Pharmakologie -- Pharmakogenetik (Embryotoxizität) -- Allgemeines

Subjects:

Fetal Development (drug effects)

Abnormalities, Drug-Induced

Reproduction (drug effects)

Embryonic Development (drug effects)

Reproduktionstoxikologie / Embryotoxizität

Notes: Includes bibliographical references and index
Physical Description: XVIII, 1202 S., [11] Bl, zahlr. Ill., graph. Darst., 28 cm
ISBN: 0-12-382032-4
978-0-12-382033-4
978-0-12-382032-7
Sekundärausgabe Online-Ausg., 2011

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500 |a Includes bibliographical references and index 
501 |a Front Cover; Dedication; Reproductive And Developmental Toxicology; Copyright; Contents; Foreword; List of Contributors; Section 1 - General; Chapter 1 - Introduction; Introduction; Chapter 2 - Reproductive anatomy and physiology; Introduction; Important definitions and concepts; Review of normal human reproduction; Concluding remarks and future directions; References; Chapter 3 - Bio-communication between mother and offspring; Introduction; Maternal influences on the development of the offspring; Transportation of bioactive substances between mother and offspring 
501 |a Concluding remarks and future directionsReferences; Chapter 4 - Pharmacokinetics in pregnancy; Introduction; Factors affecting pharmacokinetics in pregnancy; The fetal compartment; Maternal disease and obstetrical complications; Origins of the knowledge gap; Concluding remarks, current initiatives and future directions; References; Chapter 5 - PBPK models in reproductive and developmental toxicology; Introduction; PBPK Modeling: basic concepts and tools; PBPK Modeling in reproductive and developmental toxicology; PBPK Model applications in reproductive and developmental toxicology 
501 |a Concluding remarks and future directionsReferences; Chapter 6 - Transfer of drugs and xenobiotics through milk; Introduction; Drug excretion into breast milk; Drug disposition in the infant; Drugs that should be used with caution; Non-medicinal substances; Environmental pollutants; Concluding remarks and future directions; Acknowledgment; References; Section 2 - Safety Evaluation andToxicity Testing Models; Chapter 7 - Postmarket surveillance and regulatory considerations in reproductive and developmental toxicology: an FDA perspective; Introduction; Drugs intended for use in humans 
501 |a Vaccines intended for use in humansDrugs intended for use in animals; References; Chapter 8 - Reproductive and developmental safety evaluation of new pharmaceutical compounds; Introduction; Overview Of Human Pharmaceutical Development Process; Developmental And Reproductive Toxicity (Dart) Studies Needed For Development Of Innovative Human Pharmaceuticals; Interpretation Of Human Risk From The Reproductive And Developmental Toxicity Studies In Animals; Reproductive Risks Communication And Management; Concluding Remarks And Future Directions; References 
501 |a Chapter 9 - Relevance of animal testing and sensitivity of endpoints in reproductive and developmental toxicityIntroduction; Choice of animal test models; Non-mammalian animal models; Endpoints of reproductive toxicity; Tests and test guidelines; Types of studies; The path to alternative tests and conclusions; References; Chapter 10 - OECD guidelines and validated methods for in vivo testing of reproductive toxicity; Introduction; Method OECD 414 (prenatal developmental toxicity); Method OECD 415 (One-generation reproduction toxicity study) 
501 |a Method OECD 416 (two-generation reproduction toxicity study) 
501 |a Section-I: General -- Section-II: Safety Evaluation and Toxicity Testing Models -- Section-III: Nanoparticles and Radiation -- Section-IV: Gases and Solvents -- Section-V: Smoking, Alcohol, and Drugs of Abuse and Addiction -- Section-VI: Food Additives, Nutraceuticals, and Pharmaceuticals -- Section-VII: Metals -- Section-VIII: Pesticides and Other Environmental Contaminants -- Section-IX: Phytotoxicants -- Section-X: Biotoxins -- Section-XI: Special Topics -- Section-XII: Endocrine Disruption, Mutagenicity, Carcinogenicity, Infertility and Teratogenicity -- Section-XIII: Toxicologic Pathology -- Section-XIV: Placental Toxicity -- Section-XV: Domestic, Wildlife and Aquatic Species. 
520 |a Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife 
520 |a Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicologyis a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife. * Provides a complete, integrated source of information on the key risk stages during reproduction and development* Includes coverage of emerging science such as stem cell application, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory considerations, and risk assessment* Offers diverse and unique in vitroand in vivotoxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis 
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