schliessen

Filtern

 

Bibliotheken

Functional analysis of mitochondrial sirtuins in C. elegans and mammalian cells : = Funktionale Analyse mitochondrialer Sirtuine in C. elegans und Säugetierzellen / vorgelegt von Martina Wirth

Silent information regulator 2 (SIR-2) proteins, also referred to as sirtuins, are highly conserved NAD+-dependent protein deacetylases that are emerging to be important energy sensors and regulators of metabolism, stress responses and aging. The mammalian sirtuin protein family is quite complex, co... Full description

PPN (Catalogue-ID): 684835711
Nebentitel: Funktionale Analyse mitochondrialer Sirtuine in C. elegans und Säugetierzellen
Personen: Wirth, Martina
Format: eBook eBook
Language: English
Sprache der Zusammenfassung: Englisch
Published: 2010
Hochschule: Göttingen, Univ., Diss., 2010
Basisklassifikation: 42.13
42.15
35.70
Formangabe: Hochschulschrift
Physical Description: Online-Ressource (PDF-Datei: 132 S., 7.583 KB), Ill., graph. Darst.

Similar Items

Vorhandene Hefte/Bände

more (+)

Informationen zur Verfügbarkeit werden geladen

Staff View
LEADER 07077cam a2201309 4500
001 684835711
003 DE-627
005 20190310062814.0
007 cr uuu---uuuuu
008 120207s2010 xx |||||om 00| ||eng c
015 |a 13,O11  |2 dnb 
016 7 |a 1043612262  |2 DE-101 
024 7 |a urn:nbn:de:gbv:7-webdoc-3140-7  |2 urn 
035 |a (DE-627)684835711 
035 |a (DE-576)968483571X 
035 |a (DE-599)GBV684835711 
035 |a (OCoLC)838944503 
035 |a (DE-101)1043612262 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
044 |c XA-DE-NI 
082 0 |a 610  |2 23sdnb 
082 0 |a 500  |2 23sdnb 
082 0 4 |a 610  |q DNB 
084 |a 42.13  |2 bkl 
084 |a 42.15  |2 bkl 
084 |a 35.70  |2 bkl 
100 1 |a Wirth, Martina 
245 1 0 |a Functional analysis of mitochondrial sirtuins in C. elegans and mammalian cells  |b  = Funktionale Analyse mitochondrialer Sirtuine in C. elegans und Säugetierzellen  |c vorgelegt von Martina Wirth 
246 3 1 |a Funktionale Analyse mitochondrialer Sirtuine in C. elegans und Säugetierzellen 
246 3 3 |a Funktionale Analyse mitochondrialer Sirtuine in C. elegans und Säugetierzellen 
264 1 |c 2010 
300 |a Online-Ressource (PDF-Datei: 132 S., 7.583 KB)  |b Ill., graph. Darst 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
502 |a Göttingen, Univ., Diss., 2010 
520 |a Silent information regulator 2 (SIR-2) proteins, also referred to as sirtuins, are highly conserved NAD+-dependent protein deacetylases that are emerging to be important energy sensors and regulators of metabolism, stress responses and aging. The mammalian sirtuin protein family is quite complex, comprising seven members (SIRT1 to SIRT7) with different subcellular localization (nucleus, cytoplasm, and mitochondria). The mitochondrial SIRT4 remains the only mammalian sirtuin of which ADP-ribosyltransferase activity, but no NAD+-dependent deacetylase activity could be detected. SIRT4 negatively regulates insulin secretion and might be a therapeutic target for treatment of diabetes. However, this requires a better understanding of its biological and enzymatic function as well as identification of novel substrates. The simple multicellular organism C. elegans possesses only four SIR-2 variants (SIR-2.1 to SIR-2.4) that all show high sequence conservation to mammalian sirtuins. Overexpression of SIR-2.1 increases the life span of C. elegans, suggesting that these are also intriguing players in regulating longevity and in linking metabolism to aging-related processes. Whereas the majority of studies have focused on SIR-2.1, the variants SIR-2.2 and SIR-2.3, which are most homologous to mammalian SIRT4, remain by and large uncharacterized. In this PhD thesis I showed that SIR-2.2 and SIR-2.3 are also localized to mitochondria and are predominantly expressed in ... 
546 |a Sprache der Zusammenfassung: Englisch 
583 1 |z Langzeitarchivierung gewährleistet  |2 pdager 
655 7 |a Hochschulschrift  |0 (DE-588)4113937-9  |0 (DE-627)105825778  |0 (DE-576)209480580  |2 gnd-content 
751 |a Göttingen  |4 uvp 
776 0 8 |i Druckausg.  |a Wirth, Martina  |t Functional analysis of mitochondrial sirtuins in C. elegans and mammalian cells  |d 2010  |h Viii, 118 S.  |w (DE-627)684814900 
856 4 0 |u http://resolver.sub.uni-goettingen.de/purl/?webdoc-3140  |q text/html  |x Verlag  |z Kostenfrei  |3 Volltext 
856 4 0 |u http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7  |q text/html  |x Resolving-System  |z Kostenfrei  |3 Volltext 
856 4 0 |u http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7  |v 2013-11-12  |x Resolving-System  |3 Volltext 
856 4 0 |u http://d-nb.info/1043612262/34  |v 2013-11-12  |x Langzeitarchivierung Nationalbibliothek  |3 Volltext 
856 7 |u urn:nbn:de:gbv:7-webdoc-3140-7  |2 urn 
912 |a GBV-ODiss 
912 |a GBV_ILN_20 
912 |a SYSFLAG_1 
912 |a GBV_KXP 
912 |a GBV_ILN_21 
912 |a GBV_ILN_22 
912 |a GBV_ILN_23 
912 |a GBV_ILN_30 
912 |a GBV_ILN_40 
912 |a GBV_ILN_55 
912 |a GBV_ILN_60 
912 |a GBV_ILN_63 
912 |a GBV_ILN_70 
912 |a GBV_ILN_105 
912 |a GBV_ILN_132 
912 |a GBV_ILN_213 
912 |a GBV_ILN_230 
912 |a GBV_ILN_2403 
936 b k |a 42.13  |j Molekularbiologie  |0 (DE-627)106410458 
936 b k |a 42.15  |j Zellbiologie  |0 (DE-627)106421433 
936 b k |a 35.70  |j Biochemie: Allgemeines  |0 (DE-627)106419277 
951 |a BO 
980 |2 20  |1 01  |b 1461947812  |x 0084  |y x  |z 08-03-14 
980 |2 21  |1 01  |b 1462013635  |x 0046  |y z  |z 08-03-14 
980 |2 22  |1 01  |b 1462079202  |h SUBolrd  |x 0018  |y xu  |z 08-03-14 
980 |2 23  |1 01  |b 1787692515  |h olr-d  |x 0830  |y x  |z 26-07-18 
980 |2 30  |1 01  |b 1787772071  |x 0104  |y z  |z 26-07-18 
980 |2 40  |1 01  |b 1291487735  |h 15.09.2011 11:12:09  |x 0007  |y ksn  |z 07-02-12 
980 |2 55  |1 01  |b 1305947525  |l elektronisch  |x 3055  |y x  |z 23-05-12 
980 |2 60  |1 01  |b 1462244319  |h OLRD  |x 0705  |y z  |z 08-03-14 
980 |2 63  |1 01  |b 178787625X  |h ORD  |x 3401  |y x  |z 26-07-18 
980 |2 70  |1 01  |b 1787920712  |x 0089  |y zdt  |z 26-07-18 
980 |2 105  |1 01  |b 1596149914  |x 0841  |y z  |z 21-01-16 
980 |2 132  |1 01  |b 149810875X  |h OLR-DISS  |x 0959  |y x  |z 12-08-14 
980 |2 213  |1 01  |b 1462380069  |h ORD  |x 0551  |y x  |z 08-03-14 
980 |2 230  |1 01  |b 1462433405  |h ORD  |x 0552  |y x  |z 08-03-14 
980 |2 2403  |1 01  |b 3494762139  |e n  |x 21403  |y l01  |z 18-07-19 
981 |2 20  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 21  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 22  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 23  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 30  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 40  |1 01  |y LF  |r http://resolver.sub.uni-goettingen.de/purl/?webdoc-3140 
981 |2 40  |1 01  |y LF  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 60  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 63  |1 01  |y E-Book  |y LF  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 70  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 105  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 132  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 213  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 230  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
981 |2 2403  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:7-webdoc-3140-7 
983 |2 40  |1 00  |8 00  |0 (DE-601)619462639  |a WA 000  |b Biologie 
983 |2 60  |1 01  |8 10  |a ho 
985 |2 20  |1 01  |a OLRD 
995 |2 22  |1 01  |a SUBolrd 
995 |2 23  |1 01  |a olr-d 
995 |2 40  |1 01  |a 15.09.2011 11:12:09 
995 |2 60  |1 01  |a OLRD 
995 |2 63  |1 01  |a ORD 
995 |2 132  |1 01  |a OLR-DISS 
995 |2 213  |1 01  |a ORD 
995 |2 230  |1 01  |a ORD 
998 |2 23  |1 01  |0 2018-07-26:10:53:10