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Animal models : their value in predicting drug efficacy and toxicity /

"The Global Medical Excellence Cluster (GMEC) and the New York Academy of Sciences, in collaboration with Imperial College London and King's College London, sponsored the conference "Animal Models and Their Value in Predicting Drug Efficacy and Toxicity." The goal was to provide a neutral forum to c... Full description

PPN (Catalogue-ID): 685605248
Cooperations/Conferences: Global Medical Excellence Cluster
Kongresse: Conference Animal Models and Their Value in Predicting Drug Efficacy and Toxicity 2011 New York, NY
Format: Book Book
Enthält: Have animal models of disease helped or hindered the drug discovery process? / Ann Jacqueline Hunter
Language: English
Published: Boston, Mass., Blackwell, 2011
Series: Annals of the New York Academy of Sciences Issue (Vol. 1245)
Subject Area (NLM): W1
Basisklassifikation: 46.02
58.28
44.38
44.40
Subjects:

Animal models in research (Congresses)

Diseases (Congresses, Animal models)

Drugs (Congresses, Toxicology)

Drugs (Congresses, Testing)

Drugs (Congresses, Effectiveness)

Drug Evaluation, Preclinical (Congresses)

Disease Models, Animal (Congresses)

Drug Toxicity (Congresses)

Tiermodell / Arzneimittelprüfung

Formangabe: Konferenzschrift (2011 , New York), Aufsatzsammlung, Konferenzschrift (2011 , New York, NY)
Physical Description: 64 S, Ill., graph. Darst., 26 cm
Link: Inhaltsverzeichnis
ISBN: 1-57331-875-2
978-1-57331-875-4

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490 1 |a Annals of the New York Academy of Sciences  |v Vol. 1245  |a Issue 
501 |a Have animal models of disease helped or hindered the drug discovery process? / Ann Jacqueline Hunter 
501 |a Current models and strategies in the development of antiobesity drugs / James S. Kinsey-Jones and Kevin G. Murphy 
501 |a Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms / Dennis Bruemmer ... [et al.] 
501 |a Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations / Nick Andrews ... [et al.] 
501 |a Animal welfare and the 3Rs in European biomedical research / Dominic J. Wells 
501 |a Best practices for the use of animals in toxicological research and testing / William S. Stokes 
501 |a Progress toward generating informative porcine biomedical models using induced pluripotent stem cells / Franklin West and Steven Stice 
501 |a A knockout mouse resource for the biomedical research community / K.C. Kent Lloyd 
501 |a Minimizing strain influences in a genetically modified mouse phenotyping platform / Michael D. Hayward, Olesia Buiakova, and David S. Grass 
501 |a The blessings and curses of C57BL/6 substrains in mouse genetic studies / Camron D. Bryant 
501 |a Modeling inflammation and microvascular dysfunction / Felicity N.E. Gavins 
501 |a TRPV1 and TRPA1 channels in inflammatory pain : elucidating mechanisms / Susan D. Brain 
501 |a Imaging of endocrine gene expression in a humanized transgenic rat / Julian R.E. Davis 
501 |a Systems biology of the heart : hype or hope? / T. Alexander Quinn and Peter Kohl 
501 |a Is it time for in silico simulation of drug cardiac side effects? / Gary R. Mirams and Denis Noble 
501 |a Human stem cell-derived cardiomyocytes for pharmacological and toxicological modeling / Sian E. Harding 
501 |a Humanized mice as a preclinical tool for infectious disease and biomedical research / Leonard D. Shultz ... [et al.] 
501 |a Humanized mice for the study of type 1 and type 2 diabetes / Dale L. Greiner ... [et al.] 
501 |a Deconstructing hepatitis C virus infection in humanized mice / Marcus Dorner and Alexander Ploss 
501 |a Animal models got you puzzled? : think pig / Eric M. Walters ... [et al.]. 
520 |a "The Global Medical Excellence Cluster (GMEC) and the New York Academy of Sciences, in collaboration with Imperial College London and King's College London, sponsored the conference "Animal Models and Their Value in Predicting Drug Efficacy and Toxicity." The goal was to provide a neutral forum to critically examine and discuss the traditional role of pre-clinical animal models in drug discovery, and how these models most effectively contribute to translational medicine and therapeutic development. International, multi-disciplinary clinical and basic science investigators convened to discuss and identify changes needed to increase the predictive power of various models for drug efficacy and toxicity in humans, and ways in which to further refine, reduce, and replace animal models in biomedical research in areas such as metabolic and cardiovascular disease, inflammation, pain. Other topics discussed included new technologies in bioimaging, biosimulation, bioinformatics, the generation of genetically modified animals, phenotype screening, alternatives to rodent models, the use of embryonic stem cells, patient-specific induced pluripotent stem cells, and humanized animal models. This volume presents a collection of short papers on some of the topics discussed at this important conference"--Publisher's description 
520 |a "The Global Medical Excellence Cluster (GMEC) and the New York Academy of Sciences, in collaboration with Imperial College London and King's College London, sponsored the conference "Animal Models and Their Value in Predicting Drug Efficacy and Toxicity." The goal was to provide a neutral forum to critically examine and discuss the traditional role of pre-clinical animal models in drug discovery, and how these models most effectively contribute to translational medicine and therapeutic development. International, multi-disciplinary clinical and basic science investigators convened to discuss and identify changes needed to increase the predictive power of various models for drug efficacy and toxicity in humans, and ways in which to further refine, reduce, and replace animal models in biomedical research in areas such as metabolic and cardiovascular disease, inflammation, pain. Other topics discussed included new technologies in bioimaging, biosimulation, bioinformatics, the generation of genetically modified animals, phenotype screening, alternatives to rodent models, the use of embryonic stem cells, patient-specific induced pluripotent stem cells, and humanized animal models. This volume presents a collection of short papers on some of the topics discussed at this important conference"--Publisher's description 
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