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The AH Receptor in Biology and Toxicology /

This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. F... Full description

PPN (Catalogue-ID): 751595799
Personen: Pohjanvirta, Raimo
Format: eBook eBook
Enthält: ""Title Page""; ""Copyright""; ""Preface""; ""Contributors""; ""Part I: Historical Background""; ""Chapter 1: History of Research on the AHR""; ""1.1 Introduction""; ""1.2 A Hypothesis Is Conceived, and Genetically Defined Growth and Expansion of the Hypothesis Leads to the Identification of the Ah Locus""; ""1.3 A Focus on Public Health Leads to the Identification of the Ah Receptor""; ""1.4 The 1980s: Growth and Maturation of the Paradigm""; ""1.5 Details, Details""; ""1.6 Let Us Not Forget the Toxicology""; ""1.7 Recognizing the Importance of Regulating AHR Presence and Activity""
Language: English
Published: [s.l.], Wiley, 2011
Edition: 1. Aufl.
Subject Area (NLM): WA 240
Subjects:

Receptors, Aryl Hydrocarbon (physiology)

Risk Assessment

Signal Transduction

Dioxins (toxicity)

Receptors, Aryl Hydrocarbon (agonists)

Environmental Pollutants (toxicity)

Notes: Includes bibliographical references and index
Physical Description: Online Ressource (6629 KB, 432 S.)
ISBN: 0-470-60182-5
Sekundärausgabe Online-Ausg.

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245 1 4 |a The AH Receptor in Biology and Toxicology 
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300 |a Online Ressource (6629 KB, 432 S.) 
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500 |a Includes bibliographical references and index 
501 |a ""Title Page""; ""Copyright""; ""Preface""; ""Contributors""; ""Part I: Historical Background""; ""Chapter 1: History of Research on the AHR""; ""1.1 Introduction""; ""1.2 A Hypothesis Is Conceived, and Genetically Defined Growth and Expansion of the Hypothesis Leads to the Identification of the Ah Locus""; ""1.3 A Focus on Public Health Leads to the Identification of the Ah Receptor""; ""1.4 The 1980s: Growth and Maturation of the Paradigm""; ""1.5 Details, Details""; ""1.6 Let Us Not Forget the Toxicology""; ""1.7 Recognizing the Importance of Regulating AHR Presence and Activity"" 
501 |a ""1.8 AHRE-Dependent Versus AHRE-Independent Pathways""""1.9 The Physiological Role Is Still Elusive""; ""1.10 Summary and Future of AHR Research""; ""References""; ""Part II: Ahr as a Ligand-Activated Transcription Factor""; ""Chapter 2: Overview of AHR Functional Domains and the Classical AHR Signaling Pathway: Induction of Drug Metabolizing Enzymes""; ""2.1 Introduction""; ""2.2 Induction of CYP1A1 and the AHR Battery of DMEs""; ""2.3 Defining Major Components of CYP1A1 Induction""; ""2.4 Molecular Characterization of AHR and ARNT""; ""2.5 Other Components of Induction"" 
501 |a ""2.6 The Classical Signaling Pathway of Gene Induction by AHR""""2.7 Expanding Role of the AHR/ARNT/DRE Paradigm in AHR Biology""; ""2.8 Conclusions""; ""References""; ""Chapter 3: Role of Chaperone Proteins in AHR Function""; ""3.1 Introduction""; ""3.2 Composition of the Unliganded AHR Core Complex""; ""3.3 Presence of Other Proteins in the AHR Core Complex""; ""3.4 Conclusions""; ""Acknowledgment""; ""References""; ""Chapter 4: AHR Ligands: Promiscuity in Binding and Diversity in Response""; ""4.1 The Ah Receptor""; ""4.2 AHR Ligands""; ""4.3 AHR Ligand Binding Domain"" 
501 |a ""4.3 Promiscuity in Ligand-Dependent AHR Activation""""4.4 Conclusions""; ""Acknowledgments""; ""References""; ""Chapter 5: Dioxin Response Elements and Regulation of Gene Transcription""; ""5.1 The Initial Discoveries That Set the Stage: TCDD Induction of Cyp1a1 Requires Specific DNA Sequences""; ""5.2 The AHR Forms a DNA Binding Heterodimer with ARNT: Two bHLH/PAS Transcription Factors""; ""5.3 The AHR/ARNT Heterodimer Binds a Core Consensus Site and Additional Binding Motifs""; ""5.4 Regulation of “Classicâ€� TCDD-Inducible Genes by the AHR"" 
501 |a ""5.5 Gene Regulation by the AHR Involves Interactions with Numerous Transcription Factors""""5.6 Do All AHR Activities Require DNA Binding?""; ""5.7 Summary""; ""References""; ""Chapter 6: The AHR/ARNT Dimer and Transcriptional Coactivators""; ""6.1 Newly Identified Coactivators for the AHRC""; ""6.2 Kinetics and Topology of Coactivator Recruitments to the CYP1A1 Gene""; ""6.3 Roles of Coactivators in Transcriptional Activation of CYP1A1""; ""6.4 Role of Repressors""; ""6.5 Future Areas for Research""; ""Acknowledgments""; ""References"" 
501 |a ""Chapter 7: Regulation of AHR Activity by the AHR Repressor (AHRR)"" 
501 |a FrontmatterColor Plates -- Historical Background. History of Research on the AHR / Thomas A Gasiewicz, Ellen C Henry -- AHR as a Ligand-Activated Transcription Factor. Overview of AHR Functional Domains and the Classical AHR Signaling Pathway: Induction of Drug Metabolizing Enzymes / Qiang Ma -- Role of Chaperone Proteins in AHR Function / Iain A Murray, Gary H Perdew -- AHR Ligands: Promiscuity in Binding and Diversity in Response / Danica DeGroot, Guochun He, Domenico Fraccalvieri, Laura Bonati, Allesandro Pandini, Michael S Denison -- Dioxin Response Elements and Regulation of Gene Transcription / Hollie Swanson -- The AHR/ARNT Dimer and Transcriptional Coactivators / Oliver Hankinson -- Regulation of AHR Activity by the AHR Repressor (AHRR) / Yoshiaki Fujii-Kuriyama, Kaname Kawajiri -- Influence of HIF1a and NRF2 Signaling on AHR-Mediated Gene Expression, Toxicity, and Biological Functions / Thomas Haarmann-Stemmann, Josef Abel -- Functional Interactions of AHR with other Receptors / Sara Brunnberg, Elin Swedenborg, Jan-Ake Gustafsson -- The E3 Ubiquitin Ligase Activity of Transcription Factor AHR Permits Nongenomic Regulation of Biological Pathways / Fumiaki Ohtake, Shigeaki Kato -- Epigenetic Mechanisms in AHR Function / Chia-I Ko, Alvaro Puga -- AHR as a Mediator of Xenobiotic Toxicities: Dioxins as a Key Example. Role of the AHR and its Structure in TCDD Toxicity / Raimo Pohjanvirta, Merja Korkalainen, Ivy D Moffat, Paul C Boutros, Allan B Okey -- Nongenomic Route of Action of TCDD: Identity, Characteristics, and Toxicological Significance / Fumio Matsumura -- Interspecies Heterogeneity in the Hepatic Transcriptomic Response to AHR Activation by Dioxin / Paul C Boutros -- Dioxin-Activated AHR: Toxic Responses and the Induction of Oxidative Stress / Sidney J Stohs, Ezdihar A Hassoun -- Dioxin Activated AHR and Cancer in Laboratory Animals / Dieter Schrenk, Martin Chopra -- Teratogenic Impact of Dioxin Activated AHR in Laboratory Animals / Barbara D Abbott -- The Developmental Toxicity of Dioxin to the Developing Male Reproductive System in the Rat: Relevance of the AHR for Risk Assessment / David R Bell -- TCDD, AHR, and Immune Regulation / Nancy I Kerkvliet -- Effects of Dioxins on Teeth and Bone: The Role of AHR / Matti Viluksela, Hanna M Miettinen, Merja Korkalainen -- Impacts of Dioxin-Activated AHR Signaling in Fish and Birds / Michael T Simonich, Robert L Tanguay -- Adverse Health Outcomes Caused By Dioxin-Activated AHR in Humans / Sally S White, Suzanne E Fenton, Linda S Birnbaum -- The Toxic Equivalency Principle and its Application in Dioxin Risk Assessment / Jouko Tuomisto -- AHR-Active Compounds in the Human Diet / Stephen Safe, Gayathri Chadalapaka, Indira Jutooru -- Modulation of AHR Function by Heavy Metals and Disease States / Anwar Anwar-Mohammed, Ayman O S El-Kadi -- Transgenic Mice with a Constitutively Active AHR: A Model for Human Exposure to Dioxin and other AHR Ligands / Patrik Andersson, Sara Brunnberg, Carolina Wejheden, Lorenz Poellinger, Annika Hanberg -- AHR as a Physiological Regulator. Structural and Functional Diversification of AHRs during Metazoan Evolution / Mark E Hahn, Sibel I Karchner -- Invertebrate AHR Homologs: Ancestral Functions in Sensory Systems / Jo Anne Powell-Coffman, Hongtao Qin -- Role of AHR in the Development of the Liver and Blood Vessels / Sahoko Ichihara -- Involvement of the AHR in Cardiac Function and Regulation of Blood Pressure / Jason A Scott, Mary K Walker -- Involvement of the AHR in Development and Functioning of the Female and Male Reproductive Systems / Bethany N Karman, Isabel Herǹndez-Ochoa, Ayelet Ziv-Gal, Jodi A Flaws -- The AHR in the Control of Cell Cycle and Apoptosis / Cornelia Dietrich -- The AHR Regulates Cell Adhesion and Migration by Interacting with Oncogene and Growth Factor-Dependent Signaling / Angel Carlos Roman, Jose M Carvajal-Gonzalez, Sonia Mulero-Navarro, Aurea Gomez-Duran, Eva M Rico-Leo, Jaime M Merino, Pedro M Fernandez-Salguero -- The Physiological Role of AHR in the Mouse Immune System / Charlotte Esser -- AHR and the Circadian Clock / Shelley A Tischkau -- Index. 
520 |a This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this resource provides a comprehensive reference for readers interested in understanding the full spectrum of AHR, from basic concepts, toxicology analysis, and models to polymorphism and related diseases 
520 |a This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this resource provides a comprehensive reference for readers interested in understanding the full spectrum of AHR, from basic concepts, toxicology analysis, and models to polymorphism and related diseases. Raimo Pohjanvirta, PhD, is Professor of Toxicology at the University of Helsinki. He has been studying the effects and action mechanisms of dioxins for over twenty years, publishing over a hundred peer-reviewed papers on dioxins and AHR. Dr. Pohjanvirta has been an invited lecturer at major international conferences, including the Society of Toxicology, EUROTOX, and the British Toxicology Society. 
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650 2 |a Risk Assessment 
650 2 |a Signal Transduction 
650 2 |a Dioxins  |x toxicity 
650 2 |a Receptors, Aryl Hydrocarbon  |x agonists 
650 2 |a Environmental Pollutants  |x toxicity 
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