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Functional characterization of the local, pancreatic ß-cell renin-angiotensin system / von Carmen Härdtner

B-Zelle, Langerhans-Inseln, Insulin, Renin-Angiotensin-System, Pancreatic Beta-Cell, Islets of Langerhans, Insulin, Renin-Angiotensin System, Mas Rezeptor, Mas receptor

PPN (Catalogue-ID): 810893231
Nebentitel: beta-cell
Personen: Härdtner, Carmen
Format: eBook eBook
Language: English
Published: 2014
Hochschule: Greifswald, Univ., Diss., 2014
Basisklassifikation: 42.13
42.17
42.15
44.77
44.89
35.74
Subjects:

B-Zelle / Langerhans-Inseln / Insulin / Renin-Angiotensin-System

Formangabe: Hochschulschrift
Physical Description: Online-Ressource (PDF-Datei: 201 S., 34731 KB), Ill., graph. Darst.

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520 |a The systemic renin-angiotensin system (RAS) is an endocrine system that is mainly known to regulate blood pressure, fluid and electrolyte balance as well as volume homeostasis in the body through different active metabolites, the angiotensin (Ang) peptides. In addition, local renin-angiotensin systems have been discovered in various tissues, including the islet of Langerhans. Starting with angiotensinogen, the precursor of all angiotensin peptides which is cleaved into the decapeptide Ang I by renin, the RAS is divided into three axes. The main classical RAS axis is composed of angiotensin converting enzyme (ACE), angiotensin (Ang) II, and the Ang II type 1 receptor (AT1R), whereas the two alternative RAS axes comprise either ACE2, Ang-(1-7) and the receptor Mas or the aminopeptidase N (APN), Ang IV and the insulin-regulated aminopeptidase (IRAP). The activation of the main ACE/Ang II/AT1R RAS axis has been associated with metabolic syndrome, type 2 diabetes mellitus, and islet dysfunction. The detrimental effects resulting from the pathological activation of this axis have been shown to be attenuated or even abolished by the pharmacological inhibition of components of the main RAS axis. However, the impact of the two alternative ACE2/Ang-(1-7)/Mas and APN/Ang IV/IRAP RAS axes on islet function is less well understood. Previous studies mainly focused on the possible protective actions of Ang-(1-7) via the receptor Mas in insulin-sensitive tissues and on well known risk ... 
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