schliessen

Filtern

 

Bibliotheken

Untersuchungen zur transkriptionellen Regulation des Transporters MRP4 (ABCC4) / von Sebastian Zang

Genregulation, Proteine, Transkription, MRP4

PPN (Catalogue-ID): 840194633
Personen: Zang, Sebastian
Format: eBook eBook
Language: German
Published: 2015
Hochschule: Greifswald, Univ., Diss., 2015
Basisklassifikation: 35.76
44.38
42.20
Subjects:

Genregulation / Proteine / Transkription / Multidrug-Resistenz / ABC-Transporter / Carrier-Proteine

Formangabe: Hochschulschrift
Physical Description: Online-Ressource (PDF-Datei: 96 S., 2764 KB), Ill., graph. Darst.

Similar Items

Vorhandene Hefte/Bände

more (+)

Informationen zur Verfügbarkeit werden geladen

Staff View
LEADER 06553cam a2201249 4500
001 840194633
003 DE-627
005 20190310061215.0
007 cr uuu---uuuuu
008 151120s2015 xx |||||om 00| ||ger c
015 |a 15,O12  |2 dnb 
016 7 |a 1079072497  |2 DE-101 
024 7 |a urn:nbn:de:gbv:9-002355-9  |2 urn 
035 |a (DE-627)840194633 
035 |a (DE-599)GBV840194633 
035 |a (OCoLC)931687594 
035 |a (DE-101)1079072497 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a ger 
044 |c XA-DE-MV 
082 0 |a 610  |2 23sdnb 
082 0 4 |a 610  |q DNB 
084 |a 35.76  |2 bkl 
084 |a 44.38  |2 bkl 
084 |a 42.20  |2 bkl 
100 1 |a Zang, Sebastian 
245 1 0 |a Untersuchungen zur transkriptionellen Regulation des Transporters MRP4 (ABCC4)  |c von Sebastian Zang 
264 1 |c 2015 
300 |a Online-Ressource (PDF-Datei: 96 S., 2764 KB)  |b Ill., graph. Darst. 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
502 |a Greifswald, Univ., Diss., 2015 
520 |a Genregulation, Proteine, Transkription, MRP4 
520 |a MRP4 (multi drug resistance protein 4) is a transporter from the ATP-binding-cassette-family (ABCC4) and has a broad spectrum of substrates including xenobiotics like cephalosporines, diuretics and cytostatic agents as well as endogenous substances like bile acids, steroids, eicosanoids and nucleotides i.e. the second messenger cAMP. MRP4 is expressed in a variety of tissue including the kidney, liver, brain, blood cells and vascular smooth muscle cells. The regulation of MRP4 is less studied, therefore this publication is aimed at the examination of the transcriptional regulation of MRP4. The promoter region of the ABCC4/MRP4-gene was cloned into a luciferase-reporter-assay. After this the influence of various substances on the transcription of MRP4 was examined in studies with Hela- and HepG2-cells. Furthermore the expression of MRP4 on protein- and mRNA-level was studied with western blot an quantitative real-time-PCR experiments. Small to no effects on the promoter activity were seen after treatment with glucocorticoids, cytokines, cGMP, Nrf2-/AhR-activators and under the influence of varying glucose concentrations but a significant influence of the intracellular cAMP-level was observed. Physiologically MRP4 mediates an efflux of cAMP. After incubation with dibutyryl-cAMP the promoter activity of MRP4 was significantly increased. This increase was also seen on mRNA and protein level. By co-incubating the cells with inhibitors of the protein kinase A (PKA) and the ... 
583 1 |z Langzeitarchivierung gewährleistet  |2 pdager 
655 7 |a Hochschulschrift  |0 (DE-588)4113937-9  |0 (DE-627)105825778  |0 (DE-576)209480580  |2 gnd-content 
689 0 0 |D s  |0 (DE-588)4122166-7  |0 (DE-627)105764442  |0 (DE-576)209549211  |a Genregulation  |2 gnd 
689 0 1 |D s  |0 (DE-588)4076388-2  |0 (DE-627)106083007  |0 (DE-576)209201738  |a Proteine  |2 gnd 
689 0 2 |D s  |0 (DE-588)4170221-9  |0 (DE-627)105403989  |0 (DE-576)209928530  |a Transkription  |2 gnd 
689 0 3 |D s  |0 (DE-588)4315848-1  |0 (DE-627)126601992  |0 (DE-576)211177490  |a Multidrug-Resistenz  |2 gnd 
689 0 4 |D s  |0 (DE-588)4472594-2  |0 (DE-627)235213845  |0 (DE-576)212791168  |a ABC-Transporter  |2 gnd 
689 0 5 |D s  |0 (DE-588)4213127-3  |0 (DE-627)105075337  |0 (DE-576)210213140  |a Carrier-Proteine  |2 gnd 
689 0 |5 (DE-627) 
751 |a Greifswald  |4 uvp 
776 0 8 |i Druckausg.  |a Zang, Sebastian  |t Untersuchungen zur transkriptionellen Regulation des Transporters MRP4 (ABCC4)  |d 2015  |h 96 S.  |w (DE-627)842612475 
856 4 0 |u https://epub.ub.uni-greifswald.de/rewrite/index/id/type/opus3-id/value/2355 
856 4 0 |u http://nbn-resolving.de/urn:nbn:de:gbv:9-002355-9  |v 2015-12-07  |x Resolving-System  |3 Volltext 
856 4 0 |u http://d-nb.info/1079072497/34  |v 2015-12-07  |x Langzeitarchivierung Nationalbibliothek  |3 Volltext 
856 4 0 |u https://epub.ub.uni-greifswald.de/rewrite/index/id/type/opus3-id/value/2355  |v 2015-12-07  |x Verlag  |z kostenfrei  |3 Volltext 
856 7 |u urn:nbn:de:gbv:9-002355-9  |2 urn 
912 |a GBV-ODiss 
912 |a GBV_ILN_20 
912 |a SYSFLAG_1 
912 |a GBV_KXP 
912 |a SSG-OPC-PHA 
912 |a GBV-ODiss 
912 |a GBV_ILN_21 
912 |a GBV-ODiss 
912 |a GBV_ILN_22 
912 |a GBV-ODiss 
912 |a GBV_ILN_40 
912 |a GBV-ODiss 
912 |a GBV_ILN_60 
912 |a GBV-ODiss 
912 |a GBV_ILN_69 
912 |a GBV-ODiss 
912 |a GBV_ILN_105 
912 |a GBV-ODiss 
912 |a GBV_ILN_132 
912 |a GBV-ODiss 
912 |a GBV_ILN_213 
912 |a GBV-ODiss 
912 |a GBV_ILN_230 
936 b k |a 35.76  |j Aminosäuren  |j Peptide  |j Eiweiße  |x Biochemie  |0 (DE-627)181571129 
936 b k |a 44.38  |j Pharmakologie  |0 (DE-627)106409743 
936 b k |a 42.20  |j Genetik  |0 (DE-627)106421441 
951 |a BO 
980 |2 20  |1 01  |b 1587616971  |x 0084  |y x  |z 08-12-15 
980 |2 21  |1 01  |b 1587627604  |x 0046  |y z  |z 08-12-15 
980 |2 22  |1 01  |b 1587638371  |h SUBolrd  |x 0018  |y xu  |z 08-12-15 
980 |2 40  |1 01  |b 1587661535  |x 0007  |y xsn  |z 08-12-15 
980 |2 60  |1 01  |b 1587672626  |h OLRD  |x 0705  |y z  |z 08-12-15 
980 |2 69  |1 01  |b 158176541X  |l ACQ  |x 0009  |y x  |z 20-11-15 
980 |2 105  |1 01  |b 1596462116  |x 0841  |y z  |z 21-01-16 
980 |2 132  |1 01  |b 1591573572  |h OLR-DISS  |x 0959  |y x  |z 19-12-15 
980 |2 213  |1 01  |b 1587700719  |h ORD  |x 0551  |y x  |z 08-12-15 
980 |2 230  |1 01  |b 1587708027  |h ORD  |x 0552  |y x  |z 08-12-15 
981 |2 20  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:9-002355-9 
981 |2 21  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:9-002355-9 
981 |2 22  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:9-002355-9 
981 |2 40  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:9-002355-9 
981 |2 60  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:9-002355-9 
981 |2 69  |1 01  |r https://epub.ub.uni-greifswald.de/rewrite/index/id/type/opus3-id/value/2355 
981 |2 105  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:9-002355-9 
981 |2 132  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:9-002355-9 
981 |2 213  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:9-002355-9 
981 |2 230  |1 01  |r http://nbn-resolving.de/urn:nbn:de:gbv:9-002355-9 
983 |2 60  |1 01  |8 10  |a ho 
983 |2 69  |1 00  |8 00  |a VK 8567 
983 |2 69  |1 00  |8 01  |a WG 1900 
985 |2 20  |1 01  |a OLRD 
995 |2 22  |1 01  |a SUBolrd 
995 |2 60  |1 01  |a OLRD 
995 |2 132  |1 01  |a OLR-DISS 
995 |2 213  |1 01  |a ORD 
995 |2 230  |1 01  |a ORD