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Der Einfluss des Redoxzustandes von CRMP2 auf die Dynamik des Zytoskeletts / vorgelegt von: Christoph Voigt

CRMP2, Grx2, MICAL, Sra1/Cyfip1, Protein-Protein-Interaktion, protein-protein interaction

PPN (Catalogue-ID): 853174431
Personen: Voigt, Christoph [VerfasserIn]
Cooperations/Conferences: Ernst-Moritz-Arndt-Universität Greifswald [Grad-verleihende Institution]
Format: eBook eBook
Language: German
Published: Greifswald, 2014
Hochschule: Dissertation, Universitätsmedizin der Ernst-Moritz-Arndt-Universität Greifswald, 2016
Basisklassifikation: 42.15
42.13
35.76
Subjects:

Protein-Protein-Wechselwirkung / Zellskelett / Glutaredoxin

Formangabe: Hochschulschrift
Notes: Literaturverzeichnis: Seite 57-67
Physical Description: 1 Online-Ressource (PDF-Datei: 78 Seiten, 9638 Kilobyte), Illustrationen (teilweise farbig), Diagramme (teilweise farbig).

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520 |a CRMP2, Grx2, MICAL, Sra1/Cyfip1, Protein-Protein-Interaktion, protein-protein interaction 
520 |a Glutaredoxins (Grxs) belong to the enzyme class of oxidoreductases and are part of the thioredoxin family of proteins. Grxs catalyze the reversible (de-)glutathionylation of proteins and the reduction of protein disulfides. These activities are crucial for various redox signaling events in the different compartments of the cell. Moreover, Grxs were implied in neuronal development, neurodegenerative diseases, and the development and progression of cancer. Mammalian genomes encode four Grxs, Grx1, Grx2, Grx3 and Grx5, with cytosolic, nuclear and mitochondrial localisation. Three isoforms of human Grx2, derived from alternative transcript variants, were characterized until today. Mitochondrial Grx2a is expressed ubiquitously, whereas the nuclear and cytosolic isoforms Grx2b and Grx2c are specific for testis and cancer cells. Grx2c is involved in the control of axonal outgrowth and thus essential for the development of the brain. The overexpression of Grx2c in HeLa cells induces a distinct elongated phenotype with numerous filopodia-like extensions, described in preceeding studies. Collapsin response mediator protein 2 (CRMP2) was identified as potential target of Grx2c. Indeed, a thiol-disulfide redox switch could be detected in CRMP2 and Grx2c was identified as specific reductase, whereas MICALs (molecule(s) interacting with CasL) were suspected to be the specific oxidases of this thiol switch. Based on these previous results, we hypothesized that the redox switch in CRMP2 ... 
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