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Beschichtung von Koronarstents im Wirbelschichtverfahren / vorgelegt von Monika Wentzlaff

Wirbelschichtverfahren, Beschichtung, Stent, Koronarstent, Fluidized-bed technology, Coating, coronary stent

PPN (Catalogue-ID): 853824460
Personen: Wentzlaff, Monika [VerfasserIn]
Cooperations/Conferences: Ernst-Moritz-Arndt-Universität Greifswald [Grad-verleihende Institution]
Format: eBook eBook
Language: German
Published: Greifswald, 2015
Hochschule: Dissertation, Ernst-Moritz-Arndt-Universität Greifswald, 2016
Basisklassifikation: 44.09
58.28
58.11
44.85
Subjects:

Wirbelschichtverfahren / Beschichtung / Stent / Koronarendoprothese

Formangabe: Hochschulschrift
Notes: Literaturverzeichnis: Seite 127-136.
Physical Description: 1 Online-Ressource (PDF-Datei: 144 Seiten, 15805 Kilobyte), Illustrationen (teilweise farbig), Diagramme (teilweise farbig).

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520 |a Wirbelschichtverfahren, Beschichtung, Stent, Koronarstent, Fluidized-bed technology, Coating, coronary stent 
520 |a Coronary stents are net like, tubular implants used for the treatment of arteriosclerotic narrowed vessels. Stent of the newer generations are coated with antiproliferative drugs to reduce the risk of re-narrowing of the treated vessel. Single coating techniques are commonly employed for stent coating. These techniques have especially been developed for the purpose of stent coating and consider the fragile and tortuous structure of the implants. Distinct disadvantages of these coating techniques are high losses of coating liquid and a low output which are leading to high production costs. To overcome these limitations the aim of this research work was to evaluate the applicability of the fluid bed technology for stent coating procedures. The fluid bed technology is well established in pharmaceutical practices for coating of high amounts of small particles with low losses. Although, the behavior of different particles (size, shape, density) in the fluid bed system is described in the literature the behavior of net like hollow bodies has not been investigated. Consequently, it is not possible to predict the processability of stents. The aim of this work was to evaluate whether the fluidized-bed system is applicable for stent coating procedures. Therefore, the fluidization behavior of stents was characterized using different air distribution plates. Moreover, the influence of process parameters, coating formulations and stents types on the coating quality was investigated. The ... 
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