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Adverse effects of engineered nanomaterials : exposure, toxicology, and impact on human health / edited by Bengt Fadeel (Institute of Environmental Medicine, Karolinska Institutet Stockholm, Sweden), Antonio Pietroiusti (University of Rome ‘Tor Vergata’, Rome, Italy), Anna A. Shvedova (National Institute for Occupational and Safety Health Morgantown, WV, United States)

Cover -- Title page -- Copyright page -- Contents -- Contributors -- About the Editors -- Preface -- Section A - Engineered nanomaterials: hazard, exposure, risk assessment -- Chapter 1 - Bio-Nano Interactions -- Introduction -- Protein Corona on Nanoparticles -- Development of the Protein Corona --... Full description

PPN (Catalogue-ID): 880640499
Personen: Fadeel, Bengt [HerausgeberIn]
Pietroiusti, Antonio [HerausgeberIn]
Shvedova, Anna A. [HerausgeberIn]
Format: eBook eBook
Language: English
Published: Saint Louis, Elsevier Science, [2017]
©2017
Edition: Second edition
Subject Area (NLM): QT 36.5
Basisklassifikation: 44.39
Subjects:

Nanostructures / adverse effects

Nanostructures / toxicity

Environmental Exposure / adverse effects

Risk Assessment

Nanostructures / therapeutic use

Physical Description: 1 Online-Ressource (488 pages)
ISBN: 978-0-12-809490-7
978-0-12-809199-9

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245 1 0 |a Adverse effects of engineered nanomaterials  |b exposure, toxicology, and impact on human health  |c edited by Bengt Fadeel (Institute of Environmental Medicine, Karolinska Institutet Stockholm, Sweden), Antonio Pietroiusti (University of Rome ‘Tor Vergata’, Rome, Italy), Anna A. Shvedova (National Institute for Occupational and Safety Health Morgantown, WV, United States) 
250 |a Second edition 
264 1 |a Saint Louis  |a London  |a San Diego  |a Cambridge, MA  |a Oxford  |b Elsevier Science  |c [2017] 
264 4 |c ©2017 
300 |a 1 Online-Ressource (488 pages) 
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520 |a Cover -- Title page -- Copyright page -- Contents -- Contributors -- About the Editors -- Preface -- Section A - Engineered nanomaterials: hazard, exposure, risk assessment -- Chapter 1 - Bio-Nano Interactions -- Introduction -- Protein Corona on Nanoparticles -- Development of the Protein Corona -- Hard Corona Versus Soft Corona -- The Biomolecule Corona Composition -- Dynamic Formation of the Biocorona -- Impact of the NP-Biomolecule Corona on Human Systems -- In Vitro Studies -- In Vivo Studies -- Microbiome Interactions -- Nanotoxicity and the Biomolecule Corona -- Conclusions -- Take-Home Messages -- Acknowledgments -- References -- Chapter 2 - Physicochemical Characterization -- Introduction -- Overview of Key Physicochemical Parameters -- Modalities of Physicochemical Characterization -- Particle Size, Size Distribution, Agglomeration, and Aggregation -- Shape -- Specific Surface Area and Porosity -- Chemical Composition, Purity, and Crystal Structure (Crystallinity) -- Surface Chemistry (and Contamination) -- Surface Charge Density and Stability in Dispersion -- Dispersibility and Solubility -- Dustiness -- Sample Preparation and Dispersion Media -- Data Collection and Interpretation -- Take-Home Messages -- Acknowledgments -- Disclaimer -- References -- Chapter 3 - Toxicity Tests: In Vitro and In Vivo -- Introduction -- Methods for Visualizing Cellular Uptake and Biodistribution -- Evaluation of Transport and Uptake of ENM In Vitro and In Vivo -- In Vitro Toxicity Tests -- Cytotoxicity Tests -- Limitations of In Vitro Tests -- New In Vitro Test Principles -- Validated Cytotoxicity Tests -- Genotoxicity Tests -- Ex Vivo Models -- In Vivo Toxicity Testing -- Toxicokinetics -- Immunological Responses -- Chronic Toxicity and Carcinogenicity -- Considerations for Selection of Toxicity Tests: In Vitro/In Vivo Comparison -- Conclusions 
520 |a Take-Home Messages -- Acknowledgments -- References -- Chapter 4 - Computational Approaches -- Introduction -- Challenges in Modeling Nanoparticle Biological Effects -- Examples of Nanotoxicology Modeling Approaches -- Quantum Chemical Studies of Toxicity of Nanoparticles -- Statistical Modeling and Machine Learning Methods -- Nanotoxicological Fingerprints to Classify Nanomaterials -- Molecular Modeling and Molecular Dynamics Methods -- Elucidating Interactions Between Nanomaterials and Proteins -- Other Modeling Approaches for Nanotoxicology -- Conclusions -- Take-Home Messages -- References -- Chapter 5 - Exposure Assessment -- Background -- How can Workers be Exposed to ENMs? -- Exposure Routes -- Characterization of Behavior of ENMs -- Challenges to Assess Exposure to ENMs -- Exposure Assessment of ENMs in Workplaces -- Evidence for Release of Engineered Nanoparticles in the Workplace -- Harmful Effects on Workers -- How to Measure Nanoparticles: Metrics -- How to Measure Nanoparticles: Measurement Strategies -- Instruments Measuring Number Concentration -- Instruments Measuring Surface Concentration -- Instruments Measuring Mass Concentration -- Instruments Giving Indirect Estimates -- Sample Collection and Characterization -- ENM Modifications After Their Release -- Workers' Protection -- Health Surveillance -- Take-Home Messages -- References -- Chapter 6 - Biomonitoring -- Introduction -- Issues in the Development of Biomarkers for Engineered Nanomaterials -- Factors Affecting Biomarkers of Exposure -- Biomarkers of Effects -- Inflammation and Oxidative Stress -- Systemic Biomarkers -- Genetic and Epigenetic Biomarkers -- Epigenetic Mechanisms -- Intercellular Communication -- Toward Nanospecific and Predictive Biomarkers -- Biomonitoring in Health Surveillance and Epidemiology -- Biomonitoring Programs: Practical and Ethical Considerations 
520 |a Conclusions -- Take-Home Messages -- References -- Chapter 7 - Regulation and Legislation -- Background -- Risk Assessment of Nanomaterials -- Regulation Areas for Nanomaterials -- United States -- Environmental/Human Health -- Toxic Substances Control Act (TSCA) -- Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) -- Other Regulations -- Food Safety and Medical Applications -- Consumer Products -- Occupational -- European Union -- Chemicals -- Industrial Chemicals -- Plant Protection Products and Biocidal Products -- Worker Protection -- Consumer Products -- Cosmetic Products Regulation -- Food Legislation -- Medicinal Products and Medical Devices -- Environmental Protection -- Korea -- Master Plans on Nanosafety Management -- Nanotechnology Relevant Standard Development -- Research Activities to Support Safety of Nanomaterials -- Japan -- Regulatory Framework -- Nanotechnology Relevant Standard Development -- Research Activities -- Take-Home Messages -- Acknowledgments -- Disclaimer -- References -- Chapter 8 - Risk Assessment and Risk Management -- Introduction -- Consideration of Exposure for Nanomaterial Risk Assessment -- Estimation of Nanomaterial Organ Burden at the Primary Site of Contact -- Estimation of Nanomaterial Systemic Exposure -- Nanomaterial Hazard Assessment by Toxicological Properties -- Nanomaterial Hazard Assessment by Local Toxicity -- Nanomaterial Hazard Assessment by Short-Term Toxicity -- Nanomaterial Hazard Assessment by Carcinogenesis -- Nanomaterial Hazard Assessment by Reproductive and Developmental Toxicity -- Grouping of Nanomaterials to Streamline Hazard and Risk Assessment -- Consideration of Cellular and Apical Effects for Nanomaterial Grouping -- Nanomaterial Risk Assessment and Risk Management -- Conclusions -- Take-Home Messages -- References 
520 |a Section B - Engineered nanomaterials: adverse effects on human health -- Chapter 9 - Respiratory System, Part One: Basic Mechanisms -- Introduction -- Nanoparticle Deposition and Clearance From the Lungs -- Aerodynamic Equivalent Diameter -- Fibers -- Platelets -- Pulmonary Responses -- Inflammation -- Fibrosis -- Genotoxicity and Carcinogenesis -- Processes and Mechanisms Underlying Particle-Induced Effects in the Pleuro-Pulmonary System -- Cellular Stress -- Oxidative Stress -- Inflammasome Activation -- Frustrated Phagocytosis -- Biopersistence -- Conclusions -- Acknowledgments -- References -- Chapter 10 - Respiratory System, Part Two: Allergy and Asthma -- Allergic Reactions and Asthma -- Engineered Nanoparticles and Allergy -- Carbon Nanotubes and Allergic Pulmonary Inflammation -- Modulation of Allergen-Induced Airway Inflammation by CNTs -- Mechanisms of CNT-Induced/Mediated Allergic Responses -- Conclusions -- Take-Home Messages -- Acknowledgments -- Disclaimer -- References -- Chapter 11 - Cardiovascular System -- Introduction -- Diagnostic Applications in Cardiovascular Disease -- Nanotechnology in Medical Imaging -- Superparamagnetic Iron Oxide Nanoparticles -- Lipid-Based Nanoparticles -- Gold Nanoparticles -- Particokinetics of Nanomaterials for Diagnostic Use -- Combustion-Derived Nanoparticles in Cardiovascular Disease -- Toxicity of Engineered Nanoparticles in Cardiovascular Disease -- In Vitro Studies -- In Vivo Studies -- Ex Vivo Studies -- Conclusions -- References -- Chapter 12 - Neurological System -- Introduction -- ENM Translocation to and Within the Nervous System -- ENM Effects on Blood-Brain Barrier Permeability and Function -- Transport Across Cell Membranes and Intercellular Transport of ENMs -- ENM Interactions With Biological Structures Including the Nervous System 
520 |a Biotransformation and Persistence of ENMs in the Nervous System -- Adverse Effects of ENMs Related to Nervous System Functions and Disease -- Nervous System Effects of In Vivo ENM Exposure -- Nanotitania -- Nanosilver -- Nanoalumina -- Nanocadmium and Quantum Dots -- Nanocarbon -- Nanocopper -- Nanogold -- Nanoiron -- Nanolead -- Nanomanganese -- Nanosilica -- Nanoceria -- Nanoscale Zinc Oxide -- In Vitro Studies of ENM Effects -- Nanotitania -- Nanosilver -- Nanoiron -- Nanocarbon -- Nanoceria -- Nanosilica -- Nanomanganese -- Quantum Dots -- In Silico Studies of ENM Effects -- Human Studies of ENM Effects -- Risk Assessment of Nanomaterials -- Take-Home Messages -- References -- Chapter 13 - Immune System -- Introduction -- Innate Immune Responses -- The Immune System Strikes Back -- Complement Activation -- Adaptive Immune Responses -- Nanomaterials and Allergies -- Immunosuppression by Nanomaterials -- Definitely Not Innocent Bystanders -- Turning the Tables: Biomedical Applications -- Take-Home Messages -- Acknowledgments -- References -- Chapter 14 - Endocrine System -- Introduction -- Which Endocrine Organs are Disrupted by NMs? -- Hypothalamus -- Pituitary Gland -- Pineal Gland -- Thyroid Gland -- Parathyroid Gland -- Gonads -- Gonads in Mammals -- Gonads in Other Animals -- Adrenal Gland -- Pancreas -- Thymus -- How Do NMs Functionally Disrupt Endocrine Organs? -- The Physicochemical Properties of NMs -- The Exposure Patterns of NMs -- The Tissue Distribution of NMs -- The Biological Mechanisms of Effects on Organs -- Take-Home Messages -- References -- Chapter 15 - Skin -- Skin Anatomy and Functions -- Functions of Skin -- Skin Morphology -- Nanoparticle Penetration -- Barrier Modifications -- Mechanical Action -- UVB-Damaged Skin -- Solvent Effects -- Carbon-Based Nanomaterials -- Quantum Dots -- TiO2 and ZnO -- Gold (Au)NPs 
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